Jackson started his first channel, Onision, in 2006. In his earliest videos, Jackson would refer to himself by the name of his channel, though he has said he initially planned on referring to himself as and being referred to as "Greg." Despite this, the name Onision stuck with him, and it has been his identity since.

Jackson created his second channel, OnisionArchive, in 2008. He never went into detail about the nature of this second channel when he started it, but it was used as a secondary channel in the same way many YouTubers utilized secondary channels at the time; as a platform for additional content, as well as to maximize on the earning power of his audience via advertisements. As of 2009, the OnisionArchive channel has been used in the way its name suggests; as a user archive.

In 2009, Jackson created the channel OnisionSpeaks (known by him and fans simply as Speaks), as a charity effort to support awareness of vegetarianism. Shortly after its conception, however, the OnisionSpeaks channel became his primary self-help and peer-advisory channel. Because of its nature, the channel has been a source of controversy for Jackson, due in part to users accusing Jackson of assigning himself a professional on the matter of depression and suicidal thoughts or behaviors. Despite these accusations, Jackson has never conveyed that he believes himself to be of expert help, and has often urged viewers to understand that he can only offer advice.

In 2011, Jackson implemented another channel, called OnisionEncore, in which he primarily video blogs. The OnisionEncore channel has the most inconsistent upload schedule of all Jackson's channels, and is not considered by him or fans as a primary channel of his.

In 2012, Jackson created his most recent channel UhOhBro, on which he uploads videos of him searching for and reacting in real-time to various topics, which he searches for on the search engine Google. The UhOhBro channel was his most updated channel in 2012, and continues to see a high volume of uploads on a regular basis.